To date, we have donated $30,000 to Children’s Hospital of Philadelphia’s Neuro-Oncology Research Program. These funds were used toward the low-grade glioma genome mapping project.

The Children’s Hospital of Philadelphia (CHOP) a formed a partnership between several instiutions to focus on discovery of genes underlying rare and common pediatric diseases. This partnership collaborates on research to sequencing and analyze pediatric brain tumors, through the Childhood Brain Tumor Tissue Consortium (CBTTC).

One study further investigated the BRAF mutation that is highly prevalent in low grade gliomas. It identified a second type of mutation of that paved the way for using another type of targeted therapy to treat these tumors. With targeted therapies, these pediatric tumors can be treated with minimal side effect to the child.

By partnering with Resnick/Storm Laboratory, Thea’s Star of Hope has committed to helping fund further research of low-grade gliomas, at Children’s Hospital of Philadelphia, in the coming year. This funding will help further research through the CBTTC.

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“Low-grade gliomas (also called astrocytomas) are the most common type of brain tumor in children. They can occur anywhere within the central nervous system, and when not able to be removed surgically can be very difficult to treat. At the Children’s Hospital of Philadelphia (CHOP), we were one of the first groups to report identification of the KIAA1549-BRAF fusion as a prevalent genomic mutation in this group of tumors. We have since created an extensive low-grade glioma research tumor program building upon this finding as well as several additional genomic mutations that have been identified. As we continue to interrogate the genomic underpinnings of low-grade grade gliomas, we are also very focused on working with pharmaceutical companies to identify new, promising treatments. Collaborative efforts have been initiated with the Children’s Brain Tumor Tissue Consortium (CBTTC), an innovative multi-institution tumor banking project, and with the Pacific Pediatric Neuro-Oncology Consortium (PNOC), a network of 11 children’s hospitals with goal of translating the latest findings in cancer biology into better treatments. Harnessing these resources and collaborations, the Pediatric Brain Tumor Program at CHOP is at the forefront of low-grade glioma research. “